Studies on Sural Nerve Biopsies in Endemic Skeletal Fluorosis
نویسندگان
چکیده
Sural nerve biopsies from 13 patients with radiologically confirmed skeletal fluorosis were studied for myelinated fibre densities, frequency distribution of their diameters, and single teased nerve fibre preparations. It was observed that most of the biopsies showed a marked reduction in myelinated fibre densities with more than half of them involving the smaller fibres of less than 7 gm diameter. Teased fibre measurements of internodal lengths and internodal diameters point to myelinated fibre dropout being due to axonal degeneration with secondary demyelination. The selective loss of small fibres is unlikely to be due to an entrapment neuropathy alone, and possibility of primary toxic injury needs to be considered.
منابع مشابه
Neurology of endemic skeletal fluorosis.
Endemic skeletal fluorosis is widely prevalent in India and is a major public health problem. The first ever report of endemic skeletal fluorosis and neurological manifestation was from Prakasam district in Andhra Pradesh in the year 1937. Epidemiological and experimental studies in the endemic areas suggest the role of temperate climate, hard physical labor, nutritional status, presence of abn...
متن کاملEndemic skeletal fluorosis.
Teotia, M., Teotia, S. P. S., and Kunwar, K. B. (1971). Archives of Disease in Childhood, 46, 686. Endemic skeletal fluorosis. Endemic skeletal fluorosis is described in 6 children aged 11 or over. Four cases were crippled with severe deformities in the spine, hips, and knees. All showed positive phosphorus, magnesium, and nitrogen balances and excessively positive calcium balances. The skeleta...
متن کاملDietary Fluoride Intake and Associated Skeletal and Dental Fluorosis in School Age Children in Rural Ethiopian Rift Valley
An observational study was conducted to determine dietary fluoride intake, diet, and prevalence of dental and skeletal fluorosis of school age children in three fluorosis endemic districts of the Ethiopian Rift Valley having similar concentrations of fluoride (F) in drinking water (~5 mg F/L). The duplicate plate method was used to collect foods consumed by children over 24 h from 20 households...
متن کاملSural Nerves Implicated in ALS
Read any overview of amyotrophic lateral sclerosis (ALS) and you will learn that ALS affects motor nerves but not sensory nerves-but is this correct? A study by an investigative team in the Department of Neurology at Emory University in Atlanta suggests that sural nerves indeed are affected. In reviewing cases entered into the Emory University motor neuron disease registry between 1997 and 2004...
متن کاملTangier disease--a diagnostic challenge in countries endemic for leprosy.
A case of Tangier disease (TD) is reported from India. The patient had presented with indolent mononeuritis multiplex and trophic ulcers of 16 years duration mimicking Hansen's disease. He received antileprosy treatment for one and a half years. Nerve conduction studies revealed features of demyelinating neuropathy. Biopsies of the sural nerve and skin showed striking vacuolation of Schwann cel...
متن کامل